Stable angina pectoris
Marco Valgimigli1, Simone Biscaglia
1Thoraxcenter, BA 587, Erasmus MC, Rotterdam, The Netherlands, m.valgimigli@erasmusmc.nl.
Insights
Stable coronary artery disease (SCAD) is complex, with varied patient presentations and mechanisms. This review highlights key diagnostic and therapeutic advancements for SCAD patients, including novel therapies and revascularization strategies.
Area of Science:
- Cardiology
- Internal Medicine
- Vascular Medicine
Background:
- Stable coronary artery disease (SCAD) encompasses a heterogeneous patient group with diverse clinical presentations and underlying etiologies.
- Recent European Society of Cardiology guidelines provide a comprehensive overview of SCAD definition, diagnosis, and management.
- Understanding SCAD's complexity is crucial for optimizing patient care.
Purpose of the Study:
- To review and discuss novel and clinically relevant aspects of stable coronary artery disease.
- To explore specific SCAD populations, diagnostic strategies, and emerging therapeutic options.
- To analyze recent clinical trial data comparing revascularization with optimal medical therapy in SCAD.
Main Methods:
- Literature review focusing on recent European Society of Cardiology guidelines and clinical trials.
- Critical analysis of diagnostic approaches, including pretest probability assessment.
- Evaluation of novel pharmacological therapies and intracoronary functional assessment in SCAD.
Main Results:
- Discussion of SCAD patients presenting with angina and normal coronary arteries.
- Emphasis on the importance of pretest probability in guiding diagnostic workup.
- Review of emerging pharmacological treatments and revascularization strategies for SCAD.
Conclusions:
- SCAD management requires a tailored approach considering patient heterogeneity.
- Novel pharmacological therapies and refined diagnostic tools are advancing SCAD care.
- Evidence from recent trials informs the optimal medical therapy versus revascularization debate in SCAD.
Abstract:
The stable coronary artery disease (SCAD) population is a heterogeneous group of patients both for clinical presentations and for different underlying mechanisms. The recent European Society of Cardiology guidelines extensively review SCAD from its definition to patients' diagnostic and therapeutic management. In this review, we deal with five topics that, in our opinion, represent the most intriguing, novel and/or clinically relevant aspects of this complex coronary condition. Firstly, we deal with a peculiar SCAD population: patients with angina and 'normal' coronary arteries. Secondly, we reinforce the clinical importance of a diagnostic approach based on the pretest probability of disease. Thirdly, we review and critically discuss the novel pharmacological therapies for SCAD patients. Finally, we analyse the results of the most recent clinical trials comparing revascularization versus optimal medical therapy in SCAD patients and review the currently recommended use of intracoronary functional evaluation of stenosis.
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