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Optimizing the selective recognition of protein isoforms through tuning of nanoparticle hydrophobicity
Kaimin Chen1,2, Subinoy Rana1, Daniel F Moyano1
1Department of Chemistry, University of Massachusetts at Amherst, Amherst, MA 01003, USA.
Nanoscale
|May 20, 2014
Abstract:
We demonstrate that ligand hydrophobicity can be used to increase affinity and selectivity of binding between monolayer-protected cationic gold nanoparticles and β-lactoglobulin protein isoforms containing two amino acid mutations.
