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Nanosensing at the single cell level.

Tuan Vo-Dinh1

  • 1Fitzpatrick Institute for Photonics, Department of Biomedical Engineering and Department of Chemistry, Duke University, Durham, NC 27708, USA.

Spectrochimica Acta. Part B, Atomic Spectroscopy
|May 20, 2014
PubMed
Summary
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Optical nanobiosensors enable real-time detection of biotargets within single living cells. This technology offers potential for precise in vivo analysis of cellular processes and molecular signaling pathways.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cell Biology

Background:

  • Accurate in vivo detection of biotargets in living cells is crucial for understanding cellular mechanisms.
  • Existing methods may lack the specificity or real-time capabilities required for single-cell analysis.
  • Optical nanobiosensors offer a promising avenue for advanced cellular diagnostics.

Purpose of the Study:

  • To provide an overview of optical nanobiosensor development, operation, and applications.
  • To highlight the use of these sensors for in vivo detection of biotargets in individual living cells.
  • To demonstrate the potential for single-cell analysis using nanobiosensor technology.

Main Methods:

  • Development of nanobiosensors with immobilized bioreceptor probes (e.g., antibodies).
Keywords:
ApoptosisBenzopyrene tetrolBiosensorNanobiosensorSingle cell

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  • Utilizing laser excitation to generate an evanescent field for target molecule excitation.
  • Employing a photometric system to detect optical signals (e.g., fluorescence) from analyte-bioreceptor interactions.

    • Main Results:

    • Demonstrated successful detection of biospecies within living cells.
    • Illustrated the capability to analyze molecular signaling pathways, such as apoptosis.
    • Showcased the potential of nanobiosensors for high-resolution single-cell analysis.

    Conclusions:

    • Optical nanobiosensors are effective tools for in vivo detection of biotargets in single living cells.
    • The technology facilitates real-time monitoring of cellular processes and molecular events.
    • Nanobiosensors hold significant promise for advancing single-cell diagnostics and biological research.