Direct catheter-based thrombectomy in acute ischaemic stroke performed collaboratively by cardiologists, neurologists and radiologists: the single-centre pilot experience (PRAGUE-16 study)
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Updated: Aug 2, 2026

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Published on: November 27, 2013
Petr Widimsky1, Boris Koznar, Tomas Peisker
1Department of Cardiology, University Hospital Kralovske Vinohrady and the Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Insights
Direct catheter-based thrombectomy (d-CBT) involving multiple specialists shows promise for acute ischemic stroke. Early intervention within 2 hours significantly improves functional outcomes in stroke patients.
Area of Science:
- Interventional Neurology
- Cardiovascular Interventions
- Radiology
Background:
- Acute ischemic stroke requires rapid intervention to restore blood flow.
- Catheter-based thrombectomy is a key treatment, but its optimal implementation is under investigation.
Purpose of the Study:
- To evaluate the feasibility of direct catheter-based thrombectomy (d-CBT) performed collaboratively by cardiologists, neurologists, and radiologists.
- To assess outcomes in patients undergoing d-CBT for acute ischemic stroke.
Main Methods:
- Twenty-three patients with acute ischemic stroke underwent d-CBT within 6 hours of symptom onset.
- Mechanical recanalization success rates and procedural times were recorded.
- Clinical outcomes including mortality, modified Rankin Scale (mRs) scores, and functional recovery were assessed at 90 days.
Main Results:
- Mechanical recanalization was successful in 83% of patients.
- Favorable functional outcomes (mRs ≤2) were achieved in 48% of patients, with 22% experiencing full or near-full recovery.
- Patients treated within 120 minutes had significantly better outcomes (mean mRs 1.17).
Conclusions:
- Collaborative d-CBT by neurologists, cardiologists, and radiologists is a feasible and promising approach for acute ischemic stroke.
- Timely treatment, particularly within 2 hours of stroke onset, is crucial for maximizing patient benefit.
Aims:
To assess the feasibility of direct catheter-based thrombectomy (d-CBT) performed jointly by cardiologists, neurologists and radiologists.
Methods And Results:
Computed tomography (CT) was completed within <6 hours from onset of acute ischaemic stroke and excluded bleeding or developed ischaemia in 23 patients who fulfilled pre-specified entry criteria. The mean NIHSS was 17 (8-24). Mechanical recanalisation was successful in 19/23 patients (83%). The mean symptom onset – CT time was 81 min, CT – sheath insertion 47 min, sheath – reperfusion 46 min. Three patients died within 30 days, two others within 90 days (overall three-month mortality 22%). The mean mRs at 90 days for the entire group was 3.19, among survivors 2.31 and among survivors treated within <120 minutes 1.17. Favourable functional outcome (mRs ≤2) was achieved in 48% of patients. Five patients (22%) had full (mRs=0) or nearly full (mRs=1) neurologic recovery. Seven patients were able to be discharged from neurology ICU directly home after a short (<7 days) hospital stay. Two patients had symptomatic intracranial haemorrhage.
Conclusions:
Acute stroke treatment by d-CBT jointly by neurologists, cardiologists and radiologists provided promising results especially in patients reaching the cathlab within <2 hours from stroke onset.
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