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Trabeculectomy With Mitomycin-C Versus Trabeculectomy With Amniotic Membrane Transplant: A Medium-term Randomized,
Hany A Khairy1, Moataz F Elsawy
1Menoufia University Hospitals, Menoufia, Egypt.
Journal of Glaucoma
|May 22, 2014
Summary
Trabeculectomy with amniotic membrane transplant (AMT) is a safe and effective alternative to Mitomycin-C (MMC) for lowering intraocular pressure in primary open-angle glaucoma patients. Both procedures demonstrated comparable IOP reduction over 24 months.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Regenerative Medicine
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Trabeculectomy is a common surgical procedure to lower intraocular pressure (IOP) in glaucoma patients.
- Mitomycin-C (MMC) is frequently used to enhance trabeculectomy success, but carries risks.
Purpose of the Study:
- To compare the efficacy and safety of trabeculectomy with amniotic membrane transplant (AMT) versus trabeculectomy with MMC for IOP reduction in POAG.
- To evaluate the long-term IOP-lowering effect and complication rates of both surgical techniques.
Main Methods:
- A patient-masked, randomized controlled trial involving 52 eyes of 52 POAG patients.
- Participants were randomized to undergo either trabeculectomy with AMT or trabeculectomy with MMC.
- Surgical success was defined as IOP <22 mmHg and >20% reduction without medication at 24 months.
Main Results:
- Both trabeculectomy with AMT and trabeculectomy with MMC resulted in significant IOP reduction postoperatively.
- No intraoperative complications were reported in either group.
- While the AMT group showed consistently lower IOP, the difference was not statistically significant compared to the MMC group over 24 months.
Conclusions:
- Amniotic membrane transplant (AMT) shows potential as a safe and effective alternative to MMC in trabeculectomy.
- Trabeculectomy with AMT offers comparable IOP-lowering effects to MMC with a potentially reduced rate of postoperative complications.
- AMT may be a viable option for enhancing trabeculectomy outcomes in POAG management.
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