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Related Experiment Video

Updated: Apr 29, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Controlled colonic insufflation by a remotely triggered capsule for improved mucosal visualization.

Trisha Pasricha¹, Byron F Smith², Victoria R Mitchell²

¹School of Medicine, Vanderbilt University, Nashville, Tennessee, United States.

|May 22, 2014

Summary

This summary is machine-generated.

A new wireless capsule delivers carbon dioxide (CO2) for improved colon capsule endoscopy. This system enhances mucosal visualization for colorectal cancer screening without causing colon trauma.

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Last Updated: Apr 29, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Area of Science:

Gastroenterology
Medical Devices
Endoscopy

Background:

Capsule endoscopy offers an alternative to conventional colonoscopy for colorectal cancer screening.
Current limitations include poor mucosal visibility due to inadequate colonic insufflation.
A novel wireless carbon dioxide (CO2) insufflation system was developed to address this need.

Purpose of the Study:

To assess the in vivo feasibility of a novel untethered, wireless-controlled CO2 insufflation system for colonic capsule endoscopy.

Main Methods:

An observational, nonsurvival, in vivo study was conducted using five swine.
A wireless insufflation capsule was placed in porcine colons.
Measurements included insufflation volume, time, force, visualization quality, and pathological assessment.

Main Results:

The mean insufflation diameter was 32.1 mm (SD 3.9 mm).
Sufficient CO2 volume enabled complete mucosal visualization and safe endoscope passage.
Pathological examination revealed no evidence of capsule-induced trauma.

Conclusions:

The study demonstrates the feasibility of controlled colonic insufflation using an untethered capsule in vivo.
This innovation addresses a critical unmet need in the field of colon capsule endoscopy.
The technology shows promise for enhancing colorectal cancer screening via capsule endoscopy.