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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Apr 29, 2026

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

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Kidney regeneration with stem cells: an overview.

Takashi Yokoo1

  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Nephron. Experimental Nephrology
|May 24, 2014
PubMed
Summary

Kidney regeneration offers a promising alternative to dialysis for renal failure. Researchers are exploring four stem cell strategies, including scaffolds and niche implantation, to overcome the kidney

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Nephrology

Background:

  • Kidney regeneration is a critical area of research, offering a potential alternative to dialysis for treating renal failure.
  • The kidney's complex anatomy presents significant challenges to regeneration, making it one of the most difficult organs to rebuild.
  • Despite these challenges, significant efforts are underway to achieve de novo kidney regeneration using stem cells.

Purpose of the Study:

  • To explore and summarize the primary strategies for de novo kidney regeneration from stem cells.
  • To assess the potential clinical applicability of these regenerative approaches.
  • To highlight the ongoing challenges and future prospects of kidney regeneration.

Main Methods:

  • Utilizing decellularized cadaveric scaffolds for kidney tissue engineering.

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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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  • Employing blastocyst decomplementation techniques to create developmental environments.
  • Establishing nephrogenic niches for xenogeneic embryonic development.
  • Investigating the self-assembly potential of stem cells for organogenesis.

    • Main Results:

    • Identified four distinct strategies for achieving de novo kidney regeneration from stem cells.
    • These methods encompass scaffold-based, developmental manipulation, niche-based, and self-assembly approaches.
    • Each strategy holds potential for clinical translation, though extensive preparation is necessary.

    Conclusions:

    • Despite remaining challenges, including ethical considerations and the formation of chimeric structures, current research provides hope for patients with kidney failure.
    • Kidney regeneration is anticipated to become a clinical reality in the future, offering a transformative therapeutic option.
    • The development of effective kidney regeneration strategies is crucial for advancing treatments for end-stage renal disease.