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Updated: Apr 29, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Published on: February 7, 2016

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PLA/chitosan/keratin composites for biomedical applications.

Constantin Edi Tanase1, Iuliana Spiridon2

  • 1Faculty of Medical Bioengineering, 'Grigore T. Popa' University of Medicine and Pharmacy, 9-13 Kogalniceanu Street, 700454 Iasi, Romania.

Materials Science & Engineering. C, Materials for Biological Applications
|May 27, 2014
PubMed
Summary

Novel biodegradable composites blending polylactic acid (PLA), chitosan, and keratin show enhanced hardness and good cell viability. These advanced biomaterials demonstrate potential for future medical applications.

Keywords:
BiomaterialsChitosanIn vitro studiesKeratinMechanical propertiesPLA

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Area of Science:

  • Biomaterials Science
  • Polymer Science
  • Tissue Engineering

Background:

  • Polylactic acid (PLA) is a widely used biodegradable polymer, but its mechanical properties can be limiting for certain applications.
  • Chitosan and keratin are natural polymers with inherent biocompatibility and potential bioactivity.
  • Developing novel composite materials can overcome limitations of individual components and create synergistic effects.

Purpose of the Study:

  • To synthesize and characterize novel composites using PLA, chitosan, and keratin.
  • To evaluate the mechanical properties of these new biomaterials.
  • To assess the in vitro biological response of human osteosarcoma cells on the composite surfaces.

Main Methods:

  • Blend preparation technique was employed to create the PLA/chitosan/keratin composites.
  • Mechanical testing included evaluation of Young's modulus and tensile strength.
  • Surface property analysis was conducted.
  • In vitro biological assessments utilized a human osteosarcoma cell line (e.g., MG-63).

Main Results:

  • The composites exhibited an improved Young's modulus and a decrease in tensile strength compared to pure PLA.
  • A significant increase in hardness was observed in the composites.
  • The composite surfaces showed good property uptake.
  • Biological assessments indicated good cell viability and proliferation on the composite materials.

Conclusions:

  • The developed PLA/chitosan/keratin composites possess enhanced mechanical properties, particularly hardness.
  • The materials demonstrate favorable in vitro biocompatibility with osteoblast-like cells.
  • Preliminary findings suggest these novel composites hold promise for applications in the medical field, potentially as biomaterials for tissue regeneration or medical devices.