Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

426
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
426
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

468
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

192
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
192
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

267
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
267
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

404
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
404
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

962
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
962

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polydimethylsiloxane-Based Composites with Photo-Autocatalytic Properties: Surface Photooxidation, Hydrophobicity, and Nanomechanical Properties.

Polymers·2026
Same author

Polysaccharide Composites with <i>Rosa canina</i> for Sustained Anti-Inflammatory Skin Therapy.

Polymers·2025
Same author

Exploring the Characteristics of Carbon Structures Obtained from LignoBoost Lignin.

Polymers·2025
Same author

A Biopolymeric Dextran-Chitosan Delivery System for Controlled Release of Antioxidant and Anti-Inflammatory Compounds: Lignin and Curcumin.

Molecules (Basel, Switzerland)·2025
Same author

A Green Approach to Oil Spill Mitigation: New Hybrid Materials for Wastewater Treatment.

Polymers·2024
Same author

Xanthan-Polyurethane Conjugates: An Efficient Approach for Drug Delivery.

Polymers·2024

Related Experiment Video

Updated: Sep 13, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.4K

Cyclodextrins as Multifunctional Platforms in Drug Delivery and Beyond: Structural Features, Functional Applications,

Iuliana Spiridon1, Narcis Anghel1

  • 1"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica-Voda No. 41A, 700487 Iasi, Romania.

Molecules (Basel, Switzerland)
|July 30, 2025
PubMed
Summary

Cyclodextrins (CDs) are versatile cyclic oligosaccharides that improve drug solubility, stability, and delivery. This review covers their design, characterization, and pharmaceutical applications, highlighting translational potential.

Keywords:
inclusion complexesnanocarriersstimuli-responsive systems

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.5K

Related Experiment Videos

Last Updated: Sep 13, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.4K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.5K

Area of Science:

  • Biochemistry
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides known for forming inclusion complexes with guest molecules.
  • This property enhances the solubility, stability, and bioavailability of various compounds.
  • Native CDs and their chemically modified derivatives exhibit diverse structural features influencing host-guest interactions.

Purpose of the Study:

  • To review the structural characteristics and synthetic modifications of cyclodextrins.
  • To explore analytical techniques for characterizing cyclodextrin complexes.
  • To discuss the applications of cyclodextrins in pharmaceutical formulations and drug delivery systems.

Main Methods:

  • Review of literature on cyclodextrin synthesis, characterization, and applications.
  • Summary of analytical techniques including spectroscopy, thermal analysis, and molecular modeling.
  • Discussion of regulatory status and safety profiles of cyclodextrin-based systems.

Main Results:

  • Chemically modified cyclodextrins offer tailored properties for stimuli-responsive systems and targeted drug delivery.
  • Cyclodextrin applications include solubility enhancement, controlled release, and site-specific delivery via inclusion complexes, conjugates, and nanocarriers.
  • Emerging multifunctional platforms show significant biomedical relevance.

Conclusions:

  • Cyclodextrin-based systems offer significant translational potential in pharmaceutical development.
  • Further research is needed to address challenges in the design, characterization, and application of these systems.
  • Understanding the regulatory landscape and safety profiles is crucial for clinical translation.