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Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
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Roles of xenobiotic receptors in vascular pathophysiology

Lei Xiao1, Zihui Zhang, Xiaoqin Luo

  • 1Cardiovascular Research Center, School of Medicine, Xi'an Jiaotong University.

Circulation Journal : Official Journal of the Japanese Circulation Society
|May 27, 2014
PubMed

Insights

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR) regulate xenobiotic detoxification and metabolic homeostasis. These "xenobiotic receptors" are implicated in vascular diseases, offering potential therapeutic targets.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Vascular biology

Background:

  • Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR) are key transcription factors regulating xenobiotic metabolism.
  • These receptors also influence the homeostasis of lipids, glucose, and bile acids, and inflammatory pathways.
  • Dysregulation of these pathways is linked to metabolic vascular diseases.

Purpose of the Study:

  • To review the pathophysiological roles of PXR, CAR, and AhR in the vascular system.
  • To explore their potential as therapeutic targets for vascular diseases.

Main Methods:

  • Literature review of studies on PXR, CAR, and AhR.
  • Analysis of their roles in xenobiotic metabolism and endobiotic responses.
  • Examination of their involvement in metabolic vascular diseases.

Main Results:

  • PXR, CAR, and AhR are crucial for detoxification and maintaining metabolic homeostasis.
  • These receptors play significant roles in lipid, glucose, and bile acid metabolism.
  • Their functions are implicated in the pathogenesis of hyperlipidemia, atherogenesis, and hypertension.

Conclusions:

  • PXR, CAR, and AhR are pivotal in vascular pathophysiology.
  • Targeting these "xenobiotic receptors" may offer novel therapeutic strategies for vascular diseases.

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