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Autoinduction of hypertensive reactions by tranylcypromine?
P E Keck1, H G Pope, A A Nierenberg
1Laboratories for Psychiatric Research, Mailman Research Center, Belmont, Massachusetts.
Journal of Clinical Psychopharmacology
|February 1, 1989
Abstract:
Although rarely described in the psychiatric literature, patients treated with monoamine oxidase inhibitors may experience acute hypertensive reactions that are not readily attributable to dietary indiscretion or use of concomitant medications. Four cases of apparent autoinduction of hypertensive reactions in patients receiving tranylcypromine are presented. The mechanism of this reaction is unknown, but may involve conversion of tranylcypromine to metabolites with pressor activity.