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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Supramolecular cyclodextrin pseudorotaxane hydrogels: a candidate for sustained release?

Pei Lin Chee1, Ankshita Prasad1, Xiaotian Fang1

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Materials Science & Engineering. C, Materials for Biological Applications
|May 28, 2014
PubMed
Summary

Polyethylene oxide-alpha-cyclodextrin (PEO-α-CD) hydrogels release proteins via erosion. Release kinetics, influenced by PEO concentration and surface area, were best modeled by erosion-driven mechanisms.

Keywords:
BiomaterialsDrug releaseHydrogelKineticsPEO

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Hydrogels are widely used for drug delivery applications.
  • Controlling drug release kinetics from hydrogels is crucial for therapeutic efficacy.
  • Understanding the release mechanisms of encapsulated biomolecules is essential for optimizing hydrogel-based delivery systems.

Purpose of the Study:

  • To prepare PEO-α-CD pseudorotaxane hydrogels for protein delivery.
  • To investigate the release kinetics of proteins (BSA and lysozyme) from these hydrogels.
  • To elucidate the primary mechanism governing protein release from the hydrogel matrix.

Main Methods:

  • Preparation of PEO-α-CD pseudorotaxane hydrogels.
  • Encapsulation of proteins with different molecular weights (BSA and lysozyme).
  • Systematic study of protein release kinetics under varying conditions (PEO concentration, protein concentration, surface area).
  • Analysis of release data using established kinetic models (zero order, power law, Hopfenberg).

Main Results:

  • Protein release from PEO-α-CD hydrogels was observed.
  • Release kinetics were influenced by PEO concentration, protein concentration, and exposed surface area.
  • Erosion of the hydrogel surface was identified as the dominant release mechanism.
  • Release data best fitted erosion-driven models, indicating a mass-loss-dependent process.

Conclusions:

  • PEO-α-CD pseudorotaxane hydrogels facilitate protein release primarily through erosion.
  • The rate of protein release is controllable by adjusting hydrogel properties and surface area.
  • The findings provide valuable insights for designing advanced hydrogel-based drug delivery systems.