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Updated: Apr 28, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Peripheral neuropathy in children on stauvudine therapy
Naveen Sankhyan1, Rakesh Lodha, Suvasini Sharma
1Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Objective:
To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study.
Methods:
History, detailed neurological examination and nerve conduction studies were performed.
Results:
Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each.
Conclusions:
Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.
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