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Microbial Biosensors01:17

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Glucose sensing by waveguide-based absorption spectroscopy on a silicon chip.

E Ryckeboer1, R Bockstaele1, M Vanslembrouck1

  • 1Photonics Research Group, INTEC Department, Ghent University - IMEC, Sint-Pietersnieuwstraat 41,9000 Ghent, Belgium ; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.

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This study presents a novel lab-on-chip absorption spectroscopy method for label-free glucose detection. The silicon-based optofluidic sensor accurately measures glucose concentrations in aqueous solutions, paving the way for advanced diagnostics.

Keywords:
(250.5300) Photonic integrated circuits(280.1415) Biological sensing and sensors(300.1030) Absorption

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Area of Science:

  • Photonics
  • Spectroscopy
  • Biomedical Engineering

Background:

  • Accurate glucose monitoring is crucial for diabetes management.
  • Existing methods for glucose detection often require labels or are invasive.
  • Development of label-free, optical detection methods is highly desirable.

Purpose of the Study:

  • To demonstrate in vitro glucose detection using a lab-on-chip absorption spectroscopy approach.
  • To develop and validate a silicon-based optofluidic sensor for glucose measurement.
  • To explore the potential of this technology for clinical applications.

Main Methods:

  • Utilized a silicon-on-insulator (SOI) photonic chip with a spiral rib waveguide.
  • Integrated microfluidics using poly(dimethylsiloxane) (PDMS).
  • Employed evanescent absorption spectroscopy to monitor transmission spectrum changes with varying glucose concentrations.

Main Results:

  • Achieved label-free and specific glucose detection in aqueous solutions.
  • Established a linear regression model relating spectral data to glucose concentration.
  • Reported a low error-of-fitting of 1.14 mM for glucose concentration measurements.

Conclusions:

  • The lab-on-chip absorption spectroscopy approach is effective for sensitive glucose detection.
  • The developed optofluidic sensor shows promise for non-invasive glucose monitoring.
  • Further research is warranted to adapt this sensor for complex physiological samples like serum.