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Evaluation of the DDSolver software applications.
Jieyu Zuo1, Yuan Gao2, Nadia Bou-Chacra3
1Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.
Biomed Research International
|May 31, 2014
Summary
DDSolver, an Excel add-in, simplifies dissolution analysis for oral dosage forms. This software facilitates easier and more accurate drug release pattern comparisons, reducing calculation time and potential errors.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Quantitative analysis of dissolution behavior is crucial for new oral dosage forms.
- Mathematical models are essential for describing drug release patterns.
Purpose of the Study:
- To evaluate the efficacy of DDSolver, an Excel add-in, for dissolution data analysis.
- To compare DDSolver's performance against traditional Excel worksheets.
Main Methods:
- Utilized dissolution data from two separate studies involving three different products.
- Compared dissolution profile similarity factors (f2) and Korsmeyer-Peppas model release exponent (n) calculated by DDSolver and Excel.
- Assessed the ease of use and efficiency of DDSolver for routine quantitative analysis.
Main Results:
- DDSolver and Excel produced comparable similarity factors (f2) for dissolution profiles (23.21, 46.66, 17.91).
- Discrepancies were observed between DDSolver and Excel in calculating the Korsmeyer-Peppas release exponent (n).
- DDSolver demonstrated significantly easier and faster quantitative analysis compared to Excel spreadsheets.
Conclusions:
- DDSolver is a convenient tool for dissolution comparison, streamlining quantitative analysis.
- The software reduces calculation time and minimizes the risk of errors in dissolution studies.
- DDSolver offers a user-friendly alternative for analyzing drug release patterns from oral dosage forms.
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