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Updated: Apr 28, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Published on: March 6, 2013

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Enzyme structure captures four cysteines aligned for disulfide relay.

Yair Gat1, Alexandra Vardi-Kilshtain, Iris Grossman

  • 1Department of Structural Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.

Protein Science : a Publication of the Protein Society
|June 4, 2014
PubMed
Summary

Quiescin sulfhydryl oxidase (QSOX) enzymes catalyze disulfide bond formation. Crystallography revealed a unique QSOX1 conformation, offering insights into dithiol/disulfide exchange mechanisms and electron transfer energetics.

Keywords:
X-ray crystallographycis-prolineenzyme mechanismflavin adenine dinucleotidequantum mechanics/molecular mechanicsthioredoxin fold

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