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Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
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Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

Coagulation

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...

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Updated: Apr 28, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Obstetrical disseminated intravascular coagulation score.

Takao Kobayashi¹

¹Hamamatsu Medical Center, Shizuoka, Japan.

The Journal of Obstetrics and Gynaecology Research

|June 4, 2014

Summary

Obstetrical disseminated intravascular coagulation (DIC) is a serious pregnancy complication. An obstetrical DIC score aids early diagnosis and treatment, with therapy initiated at 8 points before lab results.

Keywords:

clinical symptoms efficacy evaluation criteria for obstetrical disseminated intravascular coagulation laboratory findings obstetrical disseminated intravascular coagulation score underlying diseases

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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

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Last Updated: Apr 28, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

Area of Science:

Obstetrics and Gynecology
Hematology

Background:

Obstetrical disseminated intravascular coagulation (DIC) is a critical obstetric emergency.
Prompt diagnosis and early intervention are crucial for managing this condition.

Purpose of the Study:

To introduce and validate an obstetrical DIC scoring system.
To establish criteria for evaluating the efficacy of DIC treatment in obstetrics.

Main Methods:

Development of a scoring system based on underlying diseases, clinical symptoms, and coagulation tests.
Defining criteria for treatment initiation and efficacy evaluation.

Main Results:

The obstetrical DIC score allows for prompt diagnosis and initiation of therapy.
A score of 8 or more indicates the need for immediate treatment, even before laboratory results.
Defined criteria facilitate follow-up and assessment of treatment effectiveness.

Conclusions:

The obstetrical DIC score is a valuable tool for timely diagnosis and management of DIC in pregnancy.
Established efficacy criteria enable effective monitoring of treatment outcomes in obstetrical DIC.