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Neurologic indications for therapeutic plasma exchange: 2013 update
Kelly Gwathmey1, Rasheed A Balogun, Ted Burns
1Department of Neurology, The University of Virginia, Charlottesville, Virginia.
Journal of Clinical Apheresis
|June 4, 2014
Summary
Therapeutic plasma exchange (TPE) is a common treatment for neurological disorders. This review covers its use in conditions like Guillain-Barré syndrome and myasthenia gravis, emphasizing efficacy and safety considerations.
Area of Science:
- Neurology
- Immunology
- Internal Medicine
Background:
- Therapeutic plasma exchange (TPE) is a frequently employed procedure by neurologists for managing various neurological conditions.
- Understanding the specific indications and efficacy of TPE is crucial for effective patient management.
Purpose of the Study:
- To provide a concise review of the most common neurologic indications for therapeutic plasma exchange (TPE).
- To highlight the role of TPE in specific conditions including Guillain-Barré syndrome, myasthenia gravis, and others.
Main Methods:
- Literature review focusing on established neurological conditions treated with TPE.
- Synthesis of information regarding the application of TPE in specific neuropathies and demyelinating diseases.
Main Results:
- TPE is indicated for Guillain-Barré syndrome and myasthenia gravis.
- The review details TPE's role in chronic inflammatory demyelinating polyneuropathy, Lambert-Eaton syndrome, multiple sclerosis, neuromyelitis optica, paraproteinemic polyneuropathy, Sydenham's chorea, and natalizumab-associated progressive multifocal leukoencephalopathy.
Conclusions:
- Therapeutic plasma exchange is a valuable treatment modality for several neurological disorders.
- Clinical decisions regarding TPE initiation must weigh proven efficacy against cost, potential side effects, and availability.
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