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Carbohydrate-functionalized locked nucleic acids: oligonucleotides with extraordinary binding affinity, target

Mamta Kaura1, Dale C Guenther, Patrick J Hrdlicka

  • 1Department of Chemistry, University of Idaho , Moscow, Idaho 83844-2343, United States.

Organic Letters
|June 4, 2014
PubMed
Summary

New carbohydrate-modified Locked Nucleic Acids (LNAs) show enhanced binding affinity and stability. These advanced LNA modifications improve performance in nucleic acid targeting applications like antisense technology.

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