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Gender and uveitis in patients with multiple sclerosis.
Lynn K Gordon1, Debra A Goldstein2
1Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Journal of Ophthalmology
|June 4, 2014
Summary
Multiple sclerosis (MS) is a central nervous system demyelinating disease. Patients with intermediate uveitis have an 8-12% risk of MS, particularly women with bilateral disease.
Area of Science:
- Ophthalmology
- Neurology
- Immunology
Background:
- Multiple sclerosis (MS) is a CNS demyelinating disease with higher prevalence in women.
- Ocular inflammation, including uveitis and retinal vasculitis, is associated with MS.
- Ocular symptoms can precede, coincide with, or follow neurological manifestations of MS.
Purpose of the Study:
- To highlight the association between intermediate uveitis and multiple sclerosis.
- To inform clinicians about the risk stratification for MS in uveitis patients.
- To caution against TNF inhibitor use in uveitis patients at risk for MS.
Main Methods:
- Review of existing literature on MS and ocular inflammatory diseases.
- Analysis of prevalence and risk data for MS in patients with intermediate uveitis.
- Consideration of therapeutic implications, specifically TNF inhibitors.
Main Results:
- Patients with MS have a 1% risk of intraocular inflammation.
- Patients with intermediate uveitis have an 8-12% risk of MS diagnosis.
- This risk is elevated in females and those with bilateral ocular disease.
Conclusions:
- Intermediate uveitis is a significant risk factor for MS, especially in women.
- Ophthalmologists should consider MS in patients with intermediate uveitis.
- Caution is advised with TNF inhibitors in uveitis patients due to potential MS exacerbation.
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