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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
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Colloidal drug delivery system: amplify the ocular delivery.
Javed Ali1, Mohd Fazil1, Mohd Qumbar1
1a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
Drug Delivery
|June 4, 2014
Summary
Novel colloidal drug delivery systems enhance ocular drug absorption and minimize systemic side effects, revolutionizing eye disease treatment by overcoming conventional formulation limitations.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Nanotechnology
Background:
- Ocular drug delivery faces significant challenges due to anatomical barriers and rapid clearance, leading to low therapeutic efficacy with conventional topical formulations.
- Less than 5% of conventional ocular drug doses reach intraocular tissues, with the remainder wasted or causing systemic side effects.
Purpose of the Study:
- To review the potential of colloidal drug delivery systems in improving ocular drug distribution.
- To address the limitations associated with conventional topical ocular drug formulations.
Main Methods:
- A literature review was conducted to explore constraints in ocular drug delivery.
- Recent advancements in colloidal systems, including nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers, and nanoparticle-loaded contact lenses, were summarized.
Main Results:
- Colloidal delivery systems demonstrate the capacity for targeted ocular drug distribution.
- These advanced systems offer a promising alternative to conventional methods for treating various ocular diseases.
Conclusions:
- Novel colloidal delivery systems significantly enhance ocular drug absorption.
- These systems effectively minimize systemic absorption and associated adverse effects, improving patient outcomes.
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