Development of (166)Ho-phytate Complex for Radiosynovectomy.

Area of Science:

• Nuclear Medicine
• Radiochemistry
• Biomedical Engineering

Background:

• Holmium-166 chloride ((166)Ho-chloride) was synthesized via neutron bombardment of holmium nitrate.
• The synthesis utilized a thermal neutron flux of 4-5 × 10(13) n.cm(-2).s(-1).

Purpose of the Study:

• To prepare and characterize a stable (166)Ho-phytate complex for potential radiotherapeutic applications.
• To evaluate the in vivo behavior of the (166)Ho-phytate complex following intraarticular injection in a rat model.

Main Methods:

• A high radiochemical purity ((166)Ho-phytate complex) was achieved using (166)Ho-chloride.
• Complex stability and viscosity were assessed over two days.
• Intraarticular injection into rat knee joints was performed, followed by monitoring of radioactivity leakage and organ distribution for 48 hours.

Main Results:

• The prepared (166)Ho-phytate complex exhibited high radiochemical purity (>99.9%).
• The complex remained stable and its viscosity was acceptable for injection.
• Nearly all injected radioactivity was retained at the injection site 48 hours post-injection, with minimal distribution to other organs.

Conclusions:

• The (166)Ho-phytate complex is a stable and effective agent for intraarticular injection.
• This complex shows promise as a feasible agent for cavitary radiotherapy in both oncology and rheumatology.