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Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation
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Small Macrocycles As Highly Active Integrin α2β1 Antagonists

Nis Halland1, Horst Blum1, Christian Buning1

  • 1Sanofi R&D , Industriepark Höchst Building G838, D-65926 Frankfurt am Main, Germany.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed
Summary

Researchers developed novel macrocyclic antagonists targeting the platelet collagen receptor α2β1. These potent compounds, with low nanomolar activity, show promising potential for further investigation.

Keywords:
Integrinmacrocyclemetathesisplatelet collagen receptorrestricted conformation

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