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Updated: Apr 28, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

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Predicting new Ugi-smiles couplings: a combined experimental and theoretical study.

Romain Ramozzi1, Nicolas Chéron, Laurent El Kaïm

  • 1Laboratoire de Chimie, UMR 5182, Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie F-69364 Lyon Cedex 07 (France); Laboratoire de Chimie et Procédés, DCSO, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées ParisTech, 828, Boulevard des Maréchaux, F-91762 Palaiseau Cedex (France); Département de Chimie, UMR 8640, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05 (France); Present address: Fukui Institute for Fundamental Chemistry, Kyoto University, Takano-Nishihiraki-cho 34-4, Sakyou-ku, Kyoto 606-8103 (Japan).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 7, 2014
PubMed
Summary

This study explores new substrates for Ugi-Smiles couplings using theoretical calculations. Experiments confirmed predictions, yielding aryl-imidates and providing a new route to benzimidazoles.

Keywords:
Ugi-Smiles couplingdensity functional calculationsmulticomponent reactionsnitrosophenolsprediction

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