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Virus infection cycle events coupled to RNA replication.
Pooja Saxena1, George P Lomonossoff
1Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom; email: saxenapo@indiana.edu , george.lomonossoff@jic.ac.uk.
Annual Review of Phytopathology
|June 7, 2014
Summary
Viral replication is key to virus infection. This review covers how positive-strand RNA plant viruses coordinate genome replication with other infection steps like translation and movement.
Area of Science:
- Virology
- Molecular Biology
- Plant Pathology
Background:
- Viral replication is essential for producing progeny genomes during infection.
- Positive-strand RNA viruses face unique challenges, as their genome must replicate and serve as mRNA.
- Coordinating replication with translation, encapsidation, and cell-to-cell movement is crucial for productive infection.
Purpose of the Study:
- To review the current understanding of replication-associated events in positive-strand RNA plant viruses.
- To highlight the intricate coordination between different stages of the viral infection cycle.
Main Methods:
- Literature review of recent research on positive-strand RNA plant viruses.
- Analysis of the interplay between viral genome replication and other infection processes.
Main Results:
- Replication is tightly integrated with translation, encapsidation, and movement in positive-strand RNA plant viruses.
- The viral genome serves a dual role: as a template for replication and as mRNA for protein synthesis.
- Coordination ensures efficient virus production and spread within the host plant.
Conclusions:
- The infection cycle of positive-strand RNA plant viruses is a highly coordinated process.
- Understanding these intertwined events is critical for developing strategies to control plant viral diseases.
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