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Updated: Aug 6, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Disseminated intravascular coagulation in systemic lupus erythematosus]
Anales De Medicina Interna (Madrid, Spain : 1984)
|August 1, 1989
Summary
Systemic lupus erythematosus (SLE) can cause disseminated intravascular coagulation (DIC) early in its course. Prompt treatment with corticoids and cyclophosphamide effectively resolved DIC, highlighting the importance of blood tests for SLE patients with coagulation issues.
Area of Science:
- Rheumatology
- Hematology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
- Disseminated intravascular coagulation (DIC) is a serious condition involving widespread clotting and bleeding.
- The association between early SLE and DIC without other identifiable causes is uncommon.
Observation:
- A case report detailing a patient who developed DIC at the onset of SLE.
- No alternative etiologies for DIC were identified in the patient.
- The patient's DIC resolved rapidly following treatment with corticosteroids and cyclophosphamide.
Findings:
- This case demonstrates a direct link between early-stage SLE and the development of DIC.
- Immunosuppressive therapy (corticoids and cyclophosphamide) proved effective in managing SLE-induced DIC.
- Complete blood count (CBC) and coagulation profiles are crucial for diagnosing and managing SLE complications.
Implications:
- Highlights the importance of considering DIC in SLE patients presenting with coagulation abnormalities.
- Supports the use of immunosuppressive agents in managing DIC associated with SLE.
- Emphasizes the need for comprehensive hematological evaluation in the initial workup of SLE.
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