Related Experiment Video
Updated: Apr 28, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[Urticaria in children attending allergy services]
Mario Sánchez-Borges1, Arnaldo Capriles-Hulett, Fernan Caballero-Fonseca
1Departamento de Alergología e Inmunología Clínica, Clínica El Ávila, 6a. transversal Urb. Altamira, piso 8, consultorio 803, Caracas 1060, Venezuela. sanchezbmario@gmail.com.
Insights
This study highlights key differences in pediatric urticaria triggers and subtypes between acute and chronic cases in a developing country. Findings emphasize the prevalence of spontaneous, papular, drug-induced, and dermographic urticaria in children.
Area of Science:
- Pediatric Dermatology
- Allergy and Immunology
- Epidemiology
Context:
- Limited data exists on childhood urticaria, particularly in resource-limited settings.
- Urticaria presents unique diagnostic and management challenges in pediatric populations.
Purpose:
- To investigate the demographic and clinical characteristics of pediatric urticaria in a developing country.
- To differentiate features of acute versus chronic urticaria in children.
Summary:
- A prospective study of 123 children with urticaria revealed acute urticaria is more frequent than chronic.
- Triggers varied, with insects, foods, and drugs common in acute urticaria, and skin pressure in chronic.
- Spontaneous, papular, drug-induced, and dermographic urticaria were the most common subtypes.
Impact:
- Provides crucial epidemiological data on pediatric urticaria in developing nations.
- Informs clinical practice regarding diagnosis and management of childhood urticaria.
- Highlights the need for further research into specific triggers and subtypes in diverse populations.
Background:
There is little information on urticaria occurring in children, especially in limited resource countries.
Objective:
To determine the demographic and clinical features of urticaria in children living in a developing country.
Patients And Method:
A prospective study was done in children from two allergy outpatient clinics were prospectively studied. Clinical data was obtained from the medical history and physical examination. Laboratory evaluations and immediate-type skin tests with food and aeroallergen extracts were done in selected cases. Urticaria subtypes were defined according to current EAACI/GA²LEN/WAO guidelines.
Results:
One hundred and twenty-three subjects were studied, 71 with acute urticaria and 52 with chronic urticaria. In patients with chronic urticaria, but not in those with acute urticaria, there was a significant predominance of girls. Triggers of urticaria were more common in acute than in chronic urticaria. Insects, foods, and drugs were the most common inducers of symptoms in acute urticaria, while urticaria induced by skin pressure was referred more often in chronic urticaria. In patients with acute or chronic urticaria there was a higher involvement of the head, upper and lower limbs. In patients with chronic urticaria, generalized urticaria, angioedema, and wheals on pressure sites were more frequent than in patients with acute urticaria. Spontaneous, papular, drug-induced, and dermographic urticaria were the most common subtypes in both groups of children.
Conclusions:
In children attending allergy services, acute urticaria was more frequent than the chronic type. Symptom triggers were different in acute than in chronic urticaria. Most common subtypes were spontaneous, papular, drug-induced, and dermographic urticaria.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Allergic Reactions
Allergic Drug Reactions
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

