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Leuprolide acetate-induced generalized papular eruption.

Katy Burris, Catherine Y Ding, Geoffrey F S Lim

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    This summary is machine-generated.

    A rare skin rash, papuloerythroderma of Ofuji, occurred after leuprolide acetate injections for prostate cancer. This uncommon side effect highlights the need for awareness in patients receiving this common hormonal therapy.

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    Area of Science:

    • Dermatology
    • Endocrinology
    • Oncology

    Background:

    • Leuprolide acetate is a gonadotropin-releasing hormone agonist frequently used for prostate cancer treatment.
    • Cutaneous adverse events associated with leuprolide acetate are uncommon.

    Observation:

    • A 65-year-old man developed a disseminated papular rash after receiving leuprolide acetate injections.
    • The rash exhibited clinical and histopathological characteristics consistent with papuloerythroderma of Ofuji.

    Findings:

    • This case represents a rare instance of leuprolide-induced papuloerythroderma.
    • Only one prior case of this specific drug-induced eruption has been documented.

    Implications:

    • This report emphasizes an unusual side effect of a widely prescribed medication.
    • Increased clinical vigilance for rare dermatological reactions to leuprolide acetate is warranted in prostate cancer patients.