Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rab Cascades01:25

Rab Cascades

2.8K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
2.8K
Non-gated Ion Channels01:24

Non-gated Ion Channels

3.7K
3.7K
Non-gated Ion Channels01:24

Non-gated Ion Channels

7.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.3K
Multi-pass Transmembrane Proteins and β-barrels01:09

Multi-pass Transmembrane Proteins and β-barrels

4.3K
In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
4.3K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.6K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

5.8K
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Bolaamphiphilic and Nanoparticulate Pillar[6]arene for Noncovalent/Inclusion Complexation of Doxorubicin and Mitoxantrone in Water.

ACS omega·2026
Same author

Narcissistic assembly of homochiral covalent organic cages with dehydrobenzo[12]annulene (DBA) panels.

Chemical communications (Cambridge, England)·2026
Same author

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors.

ACS chemical neuroscience·2026
Same author

Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates.

Journal of xenobiotics·2026
Same author

An Ultrafast Infrared and UV-Vis Study of the Photochemistry of 2-Naphthaloxycarbonyl Azide.

The journal of physical chemistry letters·2025
Same journal

Fluorescent merocyanines: from fundamental properties to applications as molecular probes, in bioimaging and as emissive dye aggregates.

Chemical Society reviews·2026
Same journal

Direct impure water electrolysis at industrial scale.

Chemical Society reviews·2026
Same journal

Catalytic valorization of polyolefins: from catalysts and processes to reactors.

Chemical Society reviews·2026
Same journal

Designing stable π-radicals.

Chemical Society reviews·2026
Same journal

Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.

Chemical Society reviews·2026
Same journal

Selective carbon-carbon bond cleavage involving alkene moieties.

Chemical Society reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.4K

Gated molecular baskets.

Keith Hermann1, Yian Ruan, Alex M Hardin

  • 1Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. badjic@chemistry.ohio-state.edu.

Chemical Society Reviews
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

This review details the creation and function of gated molecular baskets. These dynamic structures control guest access, offering insights into artificial gating and catalysis for chemical reactions.

More Related Videos

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

14.0K
Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

9.5K

Related Experiment Videos

Last Updated: Apr 28, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.4K
Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

14.0K
Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

9.5K

Area of Science:

  • Supramolecular Chemistry
  • Catalysis

Background:

  • Molecular baskets are concave hosts capable of encapsulating guest molecules.
  • Gated molecular baskets possess dynamic gates that regulate guest exchange.

Purpose of the Study:

  • To review the construction and mechanism of gated molecular baskets.
  • To illustrate their potential as catalysts for controlled chemical reactions.
  • To highlight their utility in studying artificial gating processes.

Main Methods:

  • Review of computational and experimental studies on gated molecular baskets.
  • Analysis of the gating mechanism involving gate unfolding at the rim.
  • Examination of guest exchange regulation.

Main Results:

  • Gated baskets demonstrate a mechanism for controlled guest passage via gate opening.
  • These systems serve as models for investigating dynamic gating in artificial constructs.
  • The controlled access of reactants to gated catalysts can influence reaction outcomes.

Conclusions:

  • Gated molecular baskets are promising tools for fundamental studies in supramolecular chemistry.
  • Their ability to control guest access has implications for designing novel catalysts.
  • Further research can explore optimizing gated catalysts for specific chemical transformations.