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Updated: Apr 28, 2026
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
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Etanercept therapy for toxic epidermal necrolysis
Andrea Paradisi1, Damiano Abeni1, Fabio Bergamo2
1Health Services Research Unit, IDI-IRCCS, Rome, Italy.
Journal of the American Academy of Dermatology
|June 15, 2014
Summary
Etanercept, a treatment for toxic epidermal necrolysis (TEN), showed promising results in a small case series. Patients with this severe drug reaction experienced rapid healing with a single dose.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Toxic epidermal necrolysis (TEN) is a severe, life-threatening drug reaction.
- Currently, no standard treatment exists for TEN.
- This study explores a novel therapeutic approach for TEN management.
Purpose of the Study:
- To evaluate the efficacy of etanercept in treating patients with TEN.
- To describe the treatment outcomes in a series of TEN cases.
Main Methods:
- A case series of 10 TEN patients was observed.
- Etanercept (50 mg) was administered as a single subcutaneous injection.
- Disease severity (SCORTEN) and time to healing (Kaplan-Meier) were analyzed.
Main Results:
- All patients achieved complete reepithelialization without adverse events.
- The median time to healing was 8.5 days.
- The treatment demonstrated a rapid and positive response.
Conclusions:
- Etanercept appears to be a potentially effective treatment for TEN.
- Tumor necrosis factor-alfa (TNF-α) may be a viable therapeutic target for TEN.
- Further research is warranted to confirm these preliminary findings.
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