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Quantifying Agonist Activity at G Protein-coupled Receptors
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Constitutive activity in gonadotropin receptors

Alfredo Ulloa-Aguirre1, Eric Reiter2, George Bousfield3

  • 1Studium Consortium for Research and Training in Reproductive Sciences (sCORTS), Tours, France; Research Support Network, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" and Universidad Nacional Autónoma de México, México D.F., Mexico.

Advances in Pharmacology (San Diego, Calif.)
|June 17, 2014
PubMed
Summary

Constitutively active mutants (CAMs) of gonadotropin receptors are rare. Research explores their mechanisms, potential phenotypes in women, and therapeutic strategies for these receptor CAMs.

Keywords:
Constitutively active mutantsFamilial testotoxicosisFollicle-stimulating hormone receptorGain-of-function mutationsLuteinizing hormone receptorOvarian hyperstimulation syndromeReceptor activation

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