[Dynamics of ultrastructural organization of liver cells in experimental peritonitis]

In the experiment on Wistar rats by methods of light and electron microscopy an ultrastructural disorders of the liver cells in various stages of peritonitis were investigated. It was shown that the reactive phase of experimental peritonitis associates with dystrophic changes of the hepatocytes and the endotheliocytes of sinusoids. These reversible changes are explained by an adaptive response of cells to inflammation. In the toxic and especially in the terminal stages of peritonitis in submicroscopical architectonics of the hepatocytes, Kupffer cells and sinusoidal endotheliocytes, along with dystrophic changes appear destructive violations of organelles of hepatic cells that acquired an irreversible character. The proposed model let description of ultrastructural and functional disorders of the liver cells at different stages of peritonitis.