Related Experiment Video
Updated: Apr 28, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
Development of microRNA therapeutics is coming of age
Eva van Rooij1, Sakari Kauppinen2
1Hubrecht Institute, KNAW and University Medical Center, Utrecht, The Netherlands e.vanrooij@hubrecht.eu sk@bio.aau.dk.
Abstract:
MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Microorganisms in Medicine and Therapeutics
Experimental RNAi
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

