Related Experiment Video
Updated: Apr 28, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
18.5K
Secretory meningioma: a diagnostic pitfall.
Ruchita Tyagi, Rakesh Kumar Vasishta, Nandita Kakkar1
1Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian Journal of Pathology & Microbiology
|June 20, 2014
Summary
Secretory meningioma, a rare brain tumor subtype, presents diagnostic challenges due to its unique features. Accurate identification is crucial for avoiding overtreatment, as it follows a benign clinical course.
Area of Science:
- Neuropathology
- Oncology
- Surgical Pathology
Background:
- Secretory meningioma is a rare meningioma subtype with epithelial and secretory differentiation.
- It exhibits distinct radiological, morphological, and immunohistochemical characteristics.
- Variable peritumoral edema can mimic aggressive neoplasms, complicating diagnosis.
Purpose of the Study:
- To analyze the diagnostic features of secretory meningioma.
- To highlight its unique histopathological findings.
- To emphasize the importance of accurate diagnosis for patient management.
Main Methods:
- Retrospective analysis of five secretory meningioma cases over 16 years (1997-2012).
- Review of histopathology slides with special stains and immunohistochemistry.
- Retrieval and analysis of clinical details.
Main Results:
- Histopathology revealed characteristic vacuolated appearance with intracytoplasmic lumina.
- Unique hyaline inclusions were observed within lumina and intercellular spaces.
- Inclusions were PAS-diastase resistant and CEA-positive.
Conclusions:
- Secretory meningioma poses a diagnostic challenge due to its rarity and morphology.
- Correctly diagnosing this benign tumor is essential to prevent unnecessary aggressive treatment.
- Understanding its unique features aids in accurate pathological classification.
Related Concept Videos
01:18Viral Meningitis
191
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
191
01:22Bacterial Meningitis I: Introduction
11
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
11