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Is oncoplastic surgery a contraindication for accelerated partial breast radiation using the interstitial
Anna-Maria Roth1, Daniela Kauer-Dorner2, Alexandra Resch2
1Interdisciplinary Brachytherapy Unit, University of Luebeck, Luebeck, Germany.
Brachytherapy
|June 21, 2014
Summary
Accelerated partial breast irradiation (APBI) is feasible after oncoplastic surgery for early breast cancer. Careful target volume definition is crucial for this breast cancer treatment, requiring further investigation.
Area of Science:
- Oncology
- Radiation Oncology
- Surgical Oncology
Background:
- Oncoplastic surgery combines breast cancer removal with cosmetic reconstruction.
- Accelerated partial breast irradiation (APBI) offers a shorter course of radiation therapy.
- Selecting appropriate patients for breast-conserving therapy is essential.
Purpose of the Study:
- To evaluate the feasibility and outcomes of APBI following oncoplastic surgery in early-stage breast cancer patients.
- To assess the efficacy and safety of APBI in a selected low-risk breast cancer cohort.
Main Methods:
- Retrospective analysis of 134 patients (136 breasts) treated between 2002-2010.
- Patients underwent breast-conserving oncoplastic surgery followed by APBI (pulse dose rate or high-dose rate).
- Target volume defined using surgical margins, imaging, and palpation.
Main Results:
- Median follow-up was 39 months; 131 patients were alive at data acquisition.
- High-dose rate APBI: 3 systemic progressions, 2 in-breast tumors in different quadrants.
- Pulse dose rate APBI: 1 local recurrence, 1 non-treatment related death. Mild side effects observed.
Conclusions:
- Multicatheter APBI appears feasible after oncoplastic surgery in selected low-risk breast cancer patients.
- Precise target volume definition is critical for successful APBI.
- Further prospective studies with extended follow-up are necessary to confirm the long-term value of this approach.
