Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

277
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
277
Allergic Reactions02:06

Allergic Reactions

26.3K
Overview
26.3K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

1.0K
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
1.0K
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

620
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
620
General Anesthesia: Overview01:24

General Anesthesia: Overview

1.1K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.1K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory Viruses, Self-Diagnosis, Early Treatment and Prophylaxis.

Viruses·2026
Same author

Anaphylaxis and Epinephrine Use in Pregnancy.

The journal of allergy and clinical immunology. In practice·2026
Same author

The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities.

The World Allergy Organization journal·2026
Same author

Toward equitable and evidence-based care in Hereditary Angioedema: Time for inclusive global guidelines.

The World Allergy Organization journal·2026
Same author

Clinical remission in allergy and clinical immunology practice: State of the art and World Allergy Organization (WAO) call to action.

The World Allergy Organization journal·2026
Same author

Rapid food desensitization supported by omalizumab, with adjunctive dupilumab for type 2 comorbidities: A pediatric case series.

The World Allergy Organization journal·2026
Same journal

Harnessing Machine Learning and Electronic Health Record Data to Improve Asthma Management.

Current allergy and asthma reports·2026
Same journal

Incorporating New Guidelines into School-Based Asthma Management.

Current allergy and asthma reports·2026
Same journal

The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.

Current allergy and asthma reports·2026
Same journal

Targeting Type 2 and Non-type 2 Asthma: Emerging Biologics and Personalized Strategies.

Current allergy and asthma reports·2026
Same journal

The Role of the Indoor Exposome in Food Allergy Development.

Current allergy and asthma reports·2026
Same journal

Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.

Current allergy and asthma reports·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.4K

Perioperative anaphylaxis.

Violeta Régnier Galvão1, Pedro Giavina-Bianchi, Mariana Castells

  • 1Division of Clinical Immunology and Allergy, University of São Paulo Medical School, Rua Doutor Bacelar, 747 ap 81, Vila Clementino, 04026-001, São Paulo, SP, Brazil, vgalvao@usp.br.

Current Allergy and Asthma Reports
|June 22, 2014
PubMed
Summary
This summary is machine-generated.

Perioperative anaphylaxis is a serious risk during surgery, affecting 1:3,500 procedures. Prompt epinephrine treatment is crucial for survival, as delayed administration increases mortality risks.

More Related Videos

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.7K
Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
09:47

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

2.3K

Related Experiment Videos

Last Updated: Apr 27, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.4K
Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.7K
Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
09:47

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

2.3K

Area of Science:

  • Anesthesiology
  • Immunology
  • Emergency Medicine

Background:

  • Perioperative anaphylaxis is a severe adverse event during surgery, with a prevalence of 1:3,500 to 1:20,000 and a mortality rate up to 9%.
  • Clinical signs include rash, bronchospasm, and hypotension, requiring immediate recognition and management.
  • Delayed epinephrine administration is linked to increased mortality, highlighting the urgency of treatment.

Purpose of the Study:

  • To review key aspects of perioperative anaphylaxis.
  • To discuss risk factors, diagnosis, and treatment strategies.
  • To identify causative agents and outline investigation and prevention methods.

Main Methods:

  • Literature review focusing on perioperative anaphylaxis.
  • Analysis of clinical presentations, diagnostic markers (serum tryptase), and treatment protocols.
  • Examination of causative agents (e.g., neuromuscular blockers, latex) and diagnostic workup (skin tests, IgE).

Main Results:

  • Neuromuscular blocking agents, latex, antibiotics, hypnotics, opioids, and colloids are common triggers for IgE-mediated anaphylaxis.
  • Serum tryptase levels aid in diagnosis, while prompt epinephrine administration is vital.
  • Specific investigations like skin tests and serum-specific IgE are recommended 4-6 weeks post-reaction.

Conclusions:

  • Perioperative anaphylaxis demands rapid diagnosis and treatment, with epinephrine as the cornerstone therapy.
  • Identifying specific triggers through specialized testing is essential for future prevention.
  • Understanding risk factors and implementing preventive measures can improve patient outcomes.