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Semaforin Sema4D in the immune system in multiple sclerosis
E M Kuklina1, T V Baidina, I Yu Danchenko
1Institute of Ecology and Genetics of Micro-Organisms, Ural Division of the Russian Academy of Sciences, Perm', Russia, ibis_07@mail.ru.
Abstract:
The expression of class IV semaforin Sema4D and its CD72 receptor on lymphocytes was studied in patients with multiple sclerosis. The disease was associated with an increase in Sema4D level on intact T lymphocytes and with its more intense shedding from the membrane of activated cell. Multiple sclerosis was also associated with a decrease of CD72 receptor expression by B lymphocytes. Possible contribution of Sema4D to the disease development via the direct effects in the CNS and the immunomodulatory effect, specifically, B cell activity regulation, was discussed.
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