Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

2.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.4K
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

4.5K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.5K
Menses Phase01:18

Menses Phase

1.5K
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
1.5K
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

1.4K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.4K
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

570
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
570

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine.

The journal of headache and pain·2026
Same author

Correction: What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study.

The journal of headache and pain·2026
Same author

Aortic stiffness and cardiac function in middle-aged women with ischemic stroke with and without migraine.

BMC neurology·2026
Same author

Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond.

The journal of headache and pain·2026
Same author

Sex-specific considerations in migraine therapy.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same author

What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study.

The journal of headache and pain·2026
Same journal

Intrinsic capacity and the trajectory of ischemic heart disease and its complications: the mediating role of insulin resistance indices.

Maturitas·2026
Same journal

Mobility limitation trajectories and longitudinal changes in delayed recall in midlife and later life: A multicohort study.

Maturitas·2026
Same journal

Digital twins in menopause: a roadmap for integrating endocrine dynamics, multisystem physiology, and precision medicine.

Maturitas·2026
Same journal

Testosterone therapy in women: Keeping pace with the evidence.

Maturitas·2026
Same journal

Diagnosis and management of androgen excess presenting after menopause.

Maturitas·2026
Same journal

Domain-specific severity of menopausal symptoms and emotional eating in midlife women.

Maturitas·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K

Migraine and perimenopause.

Khatera Ibrahimi1, Emile G M Couturier2, Antoinette MaassenVanDenBrink1

  • 1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

Maturitas
|June 24, 2014
PubMed
Summary
This summary is machine-generated.

Hormonal changes during perimenopause increase migraine incidence, particularly menstrually related migraine (MRM). Hormone replacement therapy (HRT) may stabilize hormones and improve migraines, but consider stroke risk in women with migraine with aura (MA).

Keywords:
CGRPEstradiolMenopauseMenstruationMigraine

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K

Related Experiment Videos

Last Updated: Apr 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K

Area of Science:

  • Neurology
  • Endocrinology
  • Women's Health

Background:

  • Perimenopause is characterized by hormonal instability, leading to vasomotor symptoms, mood disturbances, and increased migraine incidence.
  • While new-onset migraines can occur, the primary increase in incidence affects women with menstrually related migraine (MRM).

Purpose of the Study:

  • To explore the link between perimenopause and migraine.
  • To evaluate the potential of hormone replacement therapy (HRT) in managing perimenopausal migraines.
  • To highlight considerations for HRT in women with migraine with aura (MA).

Main Methods:

  • Review of existing literature on perimenopause, migraine, and hormone replacement therapy.
  • Analysis of the impact of hormonal fluctuations on migraine incidence.
  • Consideration of stroke risk factors in women with migraine with aura.

Main Results:

  • Hormonal instability during perimenopause significantly increases migraine incidence, especially in women with MRM.
  • Hormone replacement therapy (HRT) can stabilize hormonal fluctuations and improve migraine symptoms in some perimenopausal women.
  • Women with migraine with aura (MA) have an increased stroke risk, a crucial factor when considering HRT.

Conclusions:

  • The perimenopausal transition is a critical period for migraine management.
  • HRT offers a potential therapeutic avenue for perimenopausal migraines, but requires careful patient selection.
  • Risk stratification, particularly for stroke risk in MA patients, is essential before initiating HRT for perimenopausal migraineurs.