Related Experiment Video
Updated: Apr 27, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
11.2K
Flutamide: hirsutism in women
Joyce A Generali1, Dennis J Cada2
1Editor-in-Chief, Hospital Pharmacy , and Clinical Professor, Emeritus, Department of Pharmacy Practice, University of Kansas, School of Pharmacy , Kansas City/Lawrence, Kansas ,
Hospital Pharmacy
|June 25, 2014
Summary
This guide helps healthcare professionals find and evaluate off-label drug uses not approved by the US Food and Drug Administration (FDA). It aids in determining the rationality of these uses in patient care scenarios using published literature.
Area of Science:
- Pharmacy
- Clinical Pharmacology
- Drug Information
Background:
- Off-label drug use is common in clinical practice.
- Information on unapproved drug indications is often fragmented.
- Practitioners need reliable resources to assess off-label drug efficacy and safety.
Purpose of the Study:
- To introduce a resource for identifying and evaluating off-label drug uses.
- To provide clinicians with a tool for rational decision-making in patient care.
- To guide healthcare professionals to relevant literature on unapproved drug indications.
Main Methods:
- Extraction of information from the publication 'Off-Label Drug Facts'.
- Focus on practitioner-oriented literature reviews.
- Guidance on assessing the rationality of specific off-label drug uses.
Main Results:
- The resource facilitates quick identification of published studies on off-label drug uses.
- It enables clinicians to determine the potential rationality of these uses.
- References are provided for deeper literature review.
Conclusions:
- 'Off-Label Drug Facts' serves as a valuable tool for hospital pharmacists and clinicians.
- It supports evidence-based decision-making for unapproved drug indications.
- The resource promotes informed patient care by leveraging published literature.
Related Concept Videos
01:27Acne Infection
91
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
91
01:28Menopause
5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K
01:23Cirrhosis I: Introduction
26
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
26
01:24Graves Disease II: Pathophysiology
20
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
20
01:24Disorders of the Female Reproductive System
4.5K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.5K
01:25Hyperthyroidism I: Introduction
28
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
28