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Related Experiment Video

Updated: Apr 27, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

Aging, aerobic activity and interhemispheric communication.

Keith M McGregor¹, Kenneth M Heilman², Joe R Nocera³

¹Atlanta Rehabilitation Research and Development Center of Excellence, Department of Veteran's Affairs, Decatur, GA 30033, USA. keith.mcgregor@emory.edu.

|June 26, 2014

Summary

This summary is machine-generated.

Physically fit middle-aged adults exhibit enhanced dexterity and interhemispheric motor communication. Fitness may counteract age-related declines in motor control and brain activity.

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Area of Science:

Neuroscience
Motor Control
Aging Research

Background:

Aging is associated with bilateral primary motor cortex (M1) recruitment during unimanual tasks, unlike younger adults who show ipsilateral M1 suppression.
Increased bilateral M1 recruitment in older adults may negatively impact motor task performance.
Physical fitness is linked to improved dexterity and may preserve inhibitory and excitatory communication in aging adults.

Purpose of the Study:

To investigate the relationship between physical fitness, hand dexterity, and interhemispheric motor communication in middle-aged adults.
To compare motor performance and brain activity in physically fit versus sedentary individuals.
To determine if physical fitness mitigates age-related changes in motor control.

Main Methods:

Recruited physically fit and sedentary, right-handed middle-aged adults (40-60 years).
Assessed hand dexterity using finger tapping and peg-board tests.
Measured interhemispheric inhibition using transcranial magnetic stimulation (TMS) to determine the ipsilateral silent period.
Evaluated motor performance during a bimanual coin rotation task.

Main Results:

Physically fit participants demonstrated superior right-hand dexterity compared to sedentary individuals.
Sedentary participants showed performance deficits in their left hand during the bimanual coin rotation task, unlike the fit group.
Greater dexterity positively correlated with a longer ipsilateral silent period, indicating enhanced interhemispheric inhibition.

Conclusions:

Physical fitness is associated with better hand dexterity and improved interhemispheric motor communication in middle-aged adults.
Enhanced interhemispheric inhibition, a marker of fitness, may underlie improved motor control.
Fitness may play a crucial role in maintaining optimal motor function and brain communication during aging.