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Genomic testing in cancer: patient knowledge, attitudes, and expectations
Phillip S Blanchette1, Anna Spreafico, Fiona A Miller
1Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Cancer
|June 26, 2014
Summary
Patients with advanced cancer show strong interest in genomic testing in cancer (GTC) for improved care. However, many lack sufficient knowledge and desire further education and genetic counseling to make informed decisions.
Area of Science:
- Oncology
- Genomics
- Cancer Research
Background:
- Genomic testing in cancer (GTC) analyzes genes crucial for cancer development and growth.
- GTC is being investigated for its potential to guide personalized cancer therapy.
- Understanding patient perspectives on GTC is essential for its clinical implementation.
Purpose of the Study:
- To assess patients' knowledge, attitudes, and expectations regarding genomic testing in cancer.
- To identify factors influencing patient willingness to undergo GTC.
- To determine the need for patient education and genetic counseling in GTC.
Main Methods:
- A 42-item self-administered questionnaire was developed and administered to patients with advanced cancer.
- The study included patients referred for phase 1 clinical trials or GTC testing.
- Data were collected from 98 patients, representing a 66% response rate.
Main Results:
- 76% of patients desired more information about GTC, and 64% believed it would significantly improve their care.
- The median knowledge score for cancer genomics was 67%, significantly correlated with education level.
- While 66% would consent to a needle biopsy, only 48% felt knowledgeable enough for an informed decision, and 34% desired genetic counseling.
Conclusions:
- Patients with advanced cancer are motivated to engage with GTC.
- Further education is needed to clarify the distinction between somatic and germline mutations for patients.
- Educational initiatives and genetic counseling are crucial to support patients considering GTC.
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