Related Experiment Video

Updated: Apr 27, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

18.1K

[Targeted therapies for melanoma]

U Leiter1, F Meier, C Garbe

  • 1Zentrum für Dermato-Onkologie, Universitäts-Hautklinik, Eberhard-Karls-Universität Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Deutschland, ulrike.leiter@med.uni-tuebingen.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|June 26, 2014
PubMed

Insights

Targeted therapies and immune checkpoint blockade have significantly advanced melanoma treatment. These approaches offer improved outcomes and long-term survival possibilities for patients with unresectable metastatic melanoma.

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Context:

  • Melanoma treatment has advanced due to discoveries in BRAF oncogene mutations and immune responses.
  • Targeted therapies and immunotherapies are revolutionizing care for unresectable and metastatic melanoma.

Purpose:

  • To review the latest developments in BRAF/MEK/ERK pathway signaling and targeted therapies for melanoma.
  • To describe emerging drugs for NRAS and KIT mutations and strategies for overcoming BRAF inhibitor resistance.
  • To summarize clinical study results, including toxicity profiles, of novel melanoma treatments.

Summary:

  • Recent progress includes targeted therapies for BRAF mutations and immune checkpoint inhibitors like ipilimumab and PD-1 blockade.
  • Combination therapies are being explored to manage BRAF inhibitor resistance.
  • Selective kinase inhibitors and immune checkpoint blockade show promise for improved patient survival.

Impact:

  • Therapy for unresectable metastatic melanoma has greatly improved.
  • Long-term survival for patients with metastatic melanoma is becoming a realistic possibility.
  • Advances offer new hope and better prognoses for melanoma patients.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
A Melanoma Patient-Derived Xenograft Model07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

12.3K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
161