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Association between ERCC2 polymorphisms and glioma risk: a meta-analysis.
Li-Ming Huang1, Xi Shi, Dan-Fang Yan
1Department of Chemotherapy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China
Asian Pacific Journal of Cancer Prevention : APJCP
|June 28, 2014
Summary
This meta-analysis found that the ERCC2 rs13181 polymorphism is significantly associated with glioma risk in a dose-dependent manner. Other ERCC2 polymorphisms showed no influence on glioma susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The ERCC2 gene is crucial for nucleotide excision repair and maintaining genome integrity.
- Previous studies on ERCC2 polymorphisms and glioma risk have produced conflicting results.
Purpose of the Study:
- To clarify the association between ERCC2 polymorphisms and glioma risk through a comprehensive meta-analysis.
- To investigate the specific role of the rs13181 polymorphism in glioma development.
Main Methods:
- A systematic literature search was conducted in PubMed and EMBASE databases up to December 2, 2013.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association.
- Statistical analyses were performed using Review Manager 5 and STATA.
Main Results:
- The ERCC2 rs13181 polymorphism was significantly associated with increased glioma risk (G allele vs. T allele: OR=1.15, P=0.002).
- Rs13181 demonstrated an allele dose-dependent effect on glioma risk (e.g., GG vs. TT: OR=1.30, P=0.009).
- No significant association was found for ERCC2 polymorphisms rs238406, rs1799793, and rs1052555 with glioma risk.
Conclusions:
- The ERCC2 rs13181 polymorphism is a significant risk factor for glioma, acting in an allele dose-dependent manner.
- Other investigated ERCC2 polymorphisms (rs238406, rs1799793, rs1052555) do not appear to influence glioma susceptibility.
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