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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

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Continuous ampicillin infusion as an alternative to intermittent infusion for adult inpatients: a case series

Taku Ogawa1, Kei Kasahara1, Kazuro Ikawa2

  • 1Center for Infectious Diseases, Nara Medical University, 840 Shijo, Kashihara, Nara 634-8522, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|June 29, 2014
PubMed

Insights

Continuous ampicillin infusion offers a better alternative to intermittent dosing for hospitalized adults. This method improves drug delivery and patient quality of life, with effective serum concentrations achieved.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Intravenous ampicillin is a long-standing antibiotic treatment for diverse infections.
  • Intermittent ampicillin administration can lead to dosing errors and sleep disruption.
  • Continuous infusion presents a potential solution to these issues.

Purpose of the Study:

  • To evaluate the efficacy and safety of continuous ampicillin infusion in adult inpatients.
  • To assess ampicillin serum concentrations and their correlation with patient parameters.

Main Methods:

  • Retrospective review of five adult patients receiving continuous ampicillin infusions.
  • Measurement of ampicillin serum concentrations.
  • Correlation analysis with creatinine clearance.

Main Results:

  • Achieved ampicillin serum concentrations (11.3–32.8 μg/mL) exceeded minimum inhibitory concentrations (MICs) of susceptible organisms (≤0.06–4 μg/mL).
  • A strong correlation was observed between ampicillin serum concentrations and creatinine clearance (r² = 0.91).
  • All patients showed clinical improvement without significant complications.

Conclusions:

  • Continuous ampicillin infusion is a viable and potentially superior alternative to intermittent dosing for adult inpatients.
  • This method ensures therapeutic drug levels and enhances patient comfort and care quality.
Keywords:
AmpicillinContinuous infusionInfective endocarditis

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