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Lipidomics and Transcriptomics in Neurological Diseases
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Statins in nervous system-associated diseases: angels or devils?

Q Lei, W N Peng, H You

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    PubMed
    Summary

    Statins, used to lower cholesterol, offer cardiovascular benefits but may also impact neurological health. Clinicians should monitor for potential nervous system adverse effects, such as neuropathy, in patients using these drugs.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Statins are widely used lipid-lowering drugs for cardiovascular event reduction.
    • Beyond cholesterol reduction, statins possess pleiotropic effects including anti-inflammatory and antioxidant properties.

    Purpose of the Study:

    • To explore the dual role of statins in neurological diseases, encompassing both potential benefits and risks.
    • To highlight the importance of recognizing statin-associated adverse effects on the nervous system.

    Main Methods:

    • Literature review and synthesis of existing evidence on statin use in neurological conditions.
    • Analysis of reported benefits and adverse effects of statins in the central and peripheral nervous systems.

    Main Results:

    • Statins demonstrate potential benefits in cerebrovascular disease, neurodegenerative conditions, multiple sclerosis, and brain tumors.
    • Adverse effects include myopathies, peripheral neuropathy, intracerebral hemorrhage, cognitive impairment, and mood disturbances.

    Conclusions:

    • Statins exhibit pleiotropic effects with implications for various neurological diseases.
    • Awareness of potential neurological adverse effects, particularly neuropathy, is crucial for clinicians managing patients on statin therapy.