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Updated: Apr 27, 2026
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
Advances in targeted therapy for osteosarcoma
Wenya Zhou1, Mengze Hao, Xiaoling Du
1Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Hospital and Institute, Tianjin 300060, China and National Clinical Research Center for Cancer, Tianjin Medical University Cancer Hospital and Institute, Tianjin 300060, China.
Abstract:
Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular mechanisms of etiology and pathogenesis, therefore it remains a challenge for current therapeutic strategies to effectively treat osteosarcoma. The aim of this review is to give an overview of the molecular and mechanistic changes identified in recent years which might be new targets for the treatment of osteosarcoma. These molecules play important roles in different biological and pathological programs of osteosarcoma, including the altered oncogenes and tumor suppressor genes, molecules involved in tumor cell migration and invasion, angiogenesis, apoptosis and proliferation, miRNAs, and molecules involved in osteoclast function and multidrug resistance. Further research on these molecules in osteosarcoma will provide new insights into the target therapy for osteosarcoma.
Insights
Osteosarcoma, a challenging skeletal cancer, has unknown molecular causes. Recent research identifies new molecular targets for osteosarcoma treatment, offering hope for improved therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Osteosarcoma is an aggressive skeletal cancer with poorly understood etiology and pathogenesis.
- Current therapeutic strategies face challenges in effectively treating osteosarcoma due to its complexity.
Purpose of the Study:
- To review recent molecular and mechanistic changes in osteosarcoma.
- To identify potential new molecular targets for osteosarcoma treatment.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of molecular and mechanistic alterations in osteosarcoma.
Main Results:
- Identified key molecules involved in osteosarcoma progression, including altered oncogenes, tumor suppressor genes, and those affecting cell migration, invasion, angiogenesis, apoptosis, and proliferation.
- Highlighted the role of microRNAs (miRNAs) and molecules influencing osteoclast function and multidrug resistance.
Conclusions:
- Understanding these molecular alterations is crucial for developing targeted therapies.
- Further research into these identified molecules will provide new insights for osteosarcoma treatment strategies.
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