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Association between β2-adrenoceptor gene polymorphisms and asthma risk: an updated meta-analysis
Haojun Xie1, Yuanxiong Cheng1, Yating Huo1
1Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Plos One
|July 4, 2014
Summary
This meta-analysis suggests the beta-2 adrenoceptor Arg/Gly16 gene variant increases asthma risk in Asians. The Gln/Glu27 variant may contribute to adult asthma susceptibility.
Area of Science:
- Genetics
- Pulmonology
- Pharmacogenomics
Background:
- The beta-2 adrenoceptor gene plays multiple roles in asthma, but previous study results were inconsistent.
- Small sample sizes in prior research contributed to variability in findings.
- A meta-analysis was conducted to clarify the association between beta-2 adrenoceptor gene polymorphisms and asthma risk.
Purpose of the Study:
- To perform a meta-analysis assessing the association between beta-2 adrenoceptor gene polymorphisms and asthma risk.
- To consolidate evidence from multiple studies to provide a more robust conclusion.
Main Methods:
- A comprehensive literature search was conducted across PubMed, EMBASE, and BIOSIS Previews.
- Data from eligible studies were extracted to estimate the association between beta-2 adrenoceptor gene polymorphisms and asthma risk.
- Pooled odds ratios (OR) with 95% confidence intervals (CIs) were calculated.
Main Results:
- Thirty-seven studies with 6648 asthma patients and 15943 controls were included.
- Significant associations were found for the Arg/Gly16 polymorphism in allelic (OR = 1.06) and recessive (OR = 1.11) models.
- Subgroup analyses revealed significant associations for the Arg/Gly16 polymorphism in the Asian population and for the Gln/Glu27 polymorphism in adults.
Conclusions:
- The beta-2 adrenoceptor Arg/Gly16 polymorphism is likely associated with increased asthma risk, particularly in the Asian population.
- The Gln/Glu27 polymorphism may contribute to asthma susceptibility in adults.
