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Updated: Apr 27, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective
Xiuli Hu1, Xingang Guan, Jing Li
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.
Abstract:
This study presents both tumor-targeting ligands (cRGD) and pH-activated surface charge-conversional moiety (imidazole) decorated micelles for Dox delivery. cRGD is expected to induce preferential tumor accumulation, while imidazole switches on positive charge in a tumor acid environment, which leads to enhanced micelle uptake by tumor cells.
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