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Frequency of Celiac Disease in Children with Beta Thalassemia major

N Honar1, S Kamali2, M Karimi3

  • 1Assistant Professor of pediatric gastroenterologist, Department of gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran.

Iranian Journal of Pediatric Hematology and Oncology
|July 9, 2014
PubMed

Insights

No cases of celiac disease were found in children with beta-thalassemia major in Shiraz, Iran. Screening for celiac disease is recommended only for those exhibiting suggestive symptoms.

Area of Science:

  • Pediatric Hematology
  • Gastroenterology
  • Immunology

Background:

  • Beta-thalassemia major (B-TM) is a genetic blood disorder.
  • Patients with B-TM may present with non-specific symptoms potentially linked to other conditions.
  • Celiac disease is an autoimmune disorder triggered by gluten.

Purpose of the Study:

  • To determine the prevalence of celiac disease in children with B-TM.
  • To assess the need for routine celiac disease screening in this population.

Main Methods:

  • A cohort of 215 children with B-TM in Shiraz, Iran, were screened for celiac disease.
  • Screening involved anti-tissue transglutaminase (anti-tTG) IgA, IgA levels, and anti-tTG IgG.
  • A control group of 1500 healthy children was included for comparison.

Main Results:

  • None of the B-TM patients tested positive for anti-tissue transglutaminase IgA.
  • No positive anti-tissue transglutaminase IgG results were found in IgA-deficient patients.
  • The control group showed a 2% seroprevalence and 0.6% biopsy-proven rate of celiac disease.

Conclusions:

  • No celiac disease cases were identified among the studied children with B-TM.
  • Routine screening for celiac disease in all B-TM patients may not be necessary.
  • Targeted screening in B-TM patients with suggestive symptoms is a more reasonable approach.
Abstract

Keywords:
Celiac diseasebeta-thalassemiafrequencygrowth failure

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