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Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata
Jin Bae Weon1, Bo-Ra Yun1, Jiwoo Lee1
1Department of Medical Biomaterials Engineering, College of Biomedical Science, College of Pharmacy, Kangwon National University, Chuncheon 200-701.
Biomolecules & Therapeutics
|July 11, 2014
Summary
Steamed and fermented Codonopsis lanceolata (SFC) protects brain cells from damage. This herbal extract reduces oxidative stress and inhibits cell death pathways, offering neuroprotection.
Area of Science:
- Neuroscience
- Pharmacology
- Herbal Medicine
Background:
- Codonopsis lanceolata is traditionally used for lung inflammatory conditions.
- Previous research indicated neuroprotective effects of steamed and fermented C. lanceolata (SFC).
Purpose of the Study:
- To investigate the neuroprotective mechanisms of SFC against glutamate-induced cytotoxicity in HT22 cells.
- To elucidate the role of oxidative stress and apoptosis-related proteins in SFC's protective effects.
Main Methods:
- HT22 cells were treated with SFC and exposed to glutamate.
- Oxidative stress markers (ROS, Ca(2+), NO, glutathione, glutathione reductase) were measured.
- Expression and activity of apoptosis markers (Bax, caspase-3) were analyzed.
Main Results:
- SFC treatment significantly reduced glutamate-induced cell death in HT22 cells.
- SFC decreased reactive oxygen species (ROS), calcium (Ca(2+)), and nitric oxide (NO) levels.
- SFC restored glutathione and glutathione reductase levels and inhibited Bax and caspase-3 activity.
Conclusions:
- Steamed and fermented C. lanceolata (SFC) exhibits neuroprotective properties against glutamate toxicity.
- SFC exerts its effects through antioxidant mechanisms and by inhibiting apoptosis-related protein expression.
- SFC demonstrates potential as a therapeutic agent for neurodegenerative conditions involving oxidative stress.
